People
Reece Hart Initial concept, overall database design, and web and perl coding.
Please contact Reece with suggestions, bugs, or comments.
David Cavanaugh BLAT protein-to-genome alignment and miscellaneous programming support.
Kiran Mukhyala Many features, including JMol structure view, modelset refactoring, PMAP protein-to-genome alignment, and genome view. Also responsible for data loading and Genentech internal releases.

We gratefully acknowledge the following groups and projects for their freely distributable contributions to the community. Please cite appropriate references for any data or methods you use.

Data in Unison
ensembl
Ensembl
Ensembl 2005
Hubbard T, et al.
Nucleic Acids Res. 33:D447-D453 (Database Issue) (2005). [Full Text]
Freely available [License]
GO
GeneOntology.org
Gene Ontology: tool for the unification of biology.
The Gene Ontology Consortium.
Nature Genet. 25: 25-29 (2000). [PDF]
Freely available [License]
HGNC
HGNC
HUGO Gene Nomenclature Committee (HGNC)
Department of Biology, University College London, Wolfson House
4 Stephenson Way, London NW1 2HE, UK
http://www.genenames.org/
See Unison Origins for download date.

MINT
MINT: a Molecular INTeraction database
Zanzoni A, Montecchi-Palazzi L, Quondam M, Ausiello G, Helmer-Citterich M, Cesareni G
FEBS Lett. 513: 135-140 (2002) [PubMed]
Freely available for research [License]
NCBI
Entrez Gene, HomoloGene, Taxonomy
Database resources of the National Center for Biotechnology Information.
Wheeler DL, et al.
Nucleic Acids Res. 36:D13-21 (2008). [PubMed]

PDB
The Protein Data Bank (PDB)
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE.
Nucleic Acids Res. 28: 235-242 (2000). [PubMed]
Public domain
Pfam The Pfam Protein Families Database
Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer ELL, Studholme DJ, Yeats C, Eddy SR
Nucleic Acids Research Database Issue 32:D138-D141 (2004). [PubMed]
Freely available [License (GPL)]
SCOP
SCOP - Structural Classifcation of Proteins
SCOP database in 2004: refinements integrate structure and sequence family data.
Andreeva A, Howorth D, Brenner SE, Hubbard TJP, Chothia C, Murzin AG.
Nucleic Acid Res. 32:D226-D229 (2004). [PDF]
Freely available without license after July 1, 2004 [License]
STRING
STRING
STRING 7--recent developments in the integration and prediction of protein interactions.
von Mering C, Jensen LJ, Kuhn M, Chaffron S, Doerks T, Krüger B, Snel B, Bork P.
Nucleic Acids Res. 35:D358-62 (2006). [PubMed]
Sequence data released under Creative Commons Attribution 3.0 License.

UniProt
The Universal Protein Resource (UniProt)
Bairoch A, Apweiler R, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Natale DA, O'Donovan C, Redaschi N, Yeh LS.
Nucleic Acids Res. 33: D154-159 (2005). [PubMed]
Freely distributable after Jan 1, 2005 [License]
Software and algorithms used by Unison

Big-PI GPI prediction
Prediction of potential GPI-modification sites in proprotein sequences
Eisenhaber B, Bork P, Eisenhaber F.
JMB 292:3, 741-758 (1999).
The Bioperl toolkit: Perl modules for the life sciences.
Stajich JE, Block D, Boulez K, Brenner SE, Chervitz SA, Dagdigian C, Fuellen G, Gilbert JG, Korf I, Lapp H, Lehvaslaiho H, Matsalla C, Mungall CJ, Osborne BI, Pocock MR, Schattner P, Senger M, Stein LD, Stupka E, Wilkinson MD, Birney E.
Genome Res. 12(10):1611-8 (2002). [PubMed]
Freely available [License (Artistic)]
NCBI
NCBI
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ.
J. Mol. Biol. 215:403-410 (1990). [PubMed]
Disprot VL3H Predicting intrinsic disorder from amino acid sequence.
Obradovic Z, Peng K, Vucetic S, Radivojac P, Brown CJ, Dunker AK.
Proteins. 53 Suppl 6:566-72 (2003). [PubMed]

EMBOSS
EMBOSS: The European Molecular Biology Open Software Suite
Rice P, Longden I, Bleasby A.
Trends in Genetics 16(6): 276-277 (2000).
Freely available [License (GPL and LGPL)]
GMAP/PMAP GMAP: A Genomic Mapping and Alignment Program for mRNA and EST Sequences
Wu TD, Watanabe CK.
Bioinformatics 31:1869-75 (2005). [Abstract | Manuscript PDF]
Freely available [see file `COPYING' in package]
HMMER
HMMER
Profile Hidden Markov Models.
Eddy SR.
Bioinformatics, 14:755-763 (1998). [PDF]
Freely available [License (GPL)]

JMol
http://jmol.sourcefource.net
Freely available [License (GPL)]
Logical Depth HMMer Accelerated HMMer
Freely distributable derived data is identical to Sean Eddy's academic HMMer.
Prospect Protein threading using PROSPECT: Design and evaluation.
Xu Y, Xu D.
Proteins: Structure, Function, and Genetics. 40(3):343-54 (2000).
PSIPred Protein secondary structure prediction based on position-specific scoring matrices.
Jones DT.
J. Mol. Biol. 292:195-202 (1999).
Freely available (Para 8: "...may be made available...if access is granted free of charge...")

PyMOL
The PyMOL Molecular Graphics System
DeLano WL.
http://www.pymol.org (2002).
Freely available [License]

SignalP 3.0
Improved prediction of signal peptides: SignalP 3.0.
Bendtsen JD, Nielsen H, von Heijne G, and Brunak S.
J. Mol. Biol., 340:783-795 (2004). [PDF]
TMHMM
TMHMM 2.0c
Predicting Transmembrane Protein Topology with a Hidden Markov Model: Application to Complete Genomes.
Krogh A, Larsson B, von Heijne G, and Sonnhammer ELL.
J. Mol. Biol. 305:567-580 (2001).
Other Software used by Unison

Apache web server
Freely available [License (Apache)]
GIMP
GIMP
Freely available [License (GPL)
GNOME
GNOME
Freely available [License (GPL)
GNU/FSF
GNU/Free Software Foundation
tools
Free, of course [License (GPL or LGPL)]
Linux
Linux
Freely available [License (GPL)]
OpenOffice
OpenOffice
Varies [License]

Perl
Freely available [License (Artistic)]

PostgreSQL
Freely available [License (BSD)]
Support
Genentech Corporate site
Genentech Bioinformatics public web pages