| People |
| Reece Hart |
Initial concept, overall database design, and web and perl coding.
Please contact Reece with
suggestions, bugs, or comments.
|
| David Cavanaugh |
BLAT protein-to-genome alignment and miscellaneous programming support.
|
| Kiran Mukhyala |
Many features, including JMol structure view, modelset refactoring,
PMAP protein-to-genome alignment, and genome view. Also responsible
for data loading and Genentech internal releases.
|
We gratefully acknowledge the following groups and projects for their
freely distributable contributions to the community. Please cite
appropriate references for any data or methods you use.
| Data in Unison |
Ensembl
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Ensembl 2005
Hubbard T, et al.
Nucleic Acids Res. 33:D447-D453 (Database Issue) (2005). [Full Text]
Freely available [License]
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GeneOntology.org
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Gene Ontology: tool for the unification of biology.
The Gene Ontology Consortium.
Nature Genet. 25: 25-29 (2000). [PDF]
Freely available [License]
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HGNC
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HUGO Gene Nomenclature Committee (HGNC)
Department of Biology, University College London, Wolfson House
4 Stephenson Way, London NW1 2HE, UK
http://www.genenames.org/
See Unison Origins for
download date.
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MINT
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MINT: a Molecular INTeraction database
Zanzoni A, Montecchi-Palazzi L, Quondam M, Ausiello G, Helmer-Citterich M, Cesareni G
FEBS Lett. 513: 135-140 (2002) [PubMed]
Freely available for research [License]
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Entrez Gene, HomoloGene, Taxonomy
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Database resources of the National Center for Biotechnology Information.
Wheeler DL, et al.
Nucleic Acids Res. 36:D13-21 (2008). [PubMed]
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PDB |
The Protein Data Bank (PDB)
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE.
Nucleic Acids Res. 28: 235-242 (2000). [PubMed]
Public domain
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Pfam
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The Pfam Protein Families Database
Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer ELL, Studholme DJ, Yeats C, Eddy SR
Nucleic Acids Research Database Issue 32:D138-D141 (2004). [PubMed]
Freely available [License (GPL)]
|
SCOP - Structural Classifcation of Proteins
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SCOP database in 2004: refinements integrate structure and sequence family data.
Andreeva A, Howorth D, Brenner SE, Hubbard TJP, Chothia C, Murzin AG.
Nucleic Acid Res. 32:D226-D229 (2004). [PDF]
Freely available without license after July 1, 2004 [License]
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STRING
|
STRING 7--recent developments in the integration and prediction of protein interactions.
von Mering C, Jensen LJ, Kuhn M, Chaffron S, Doerks T, Krüger B, Snel B, Bork P.
Nucleic Acids Res. 35:D358-62 (2006). [PubMed]
Sequence data released under Creative Commons Attribution 3.0 License.
|
UniProt |
The Universal Protein Resource (UniProt)
Bairoch A, Apweiler R, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Natale DA, O'Donovan C, Redaschi N, Yeh LS.
Nucleic Acids Res. 33: D154-159 (2005). [PubMed]
Freely distributable after Jan 1, 2005 [License]
|
| Software and algorithms used by Unison |
Big-PI GPI prediction
|
Prediction of potential GPI-modification sites in proprotein sequences
Eisenhaber B, Bork P, Eisenhaber F.
JMB 292:3, 741-758 (1999).
|
|
The Bioperl toolkit: Perl modules for the life sciences.
Stajich JE, Block D, Boulez K, Brenner SE, Chervitz SA, Dagdigian C, Fuellen G, Gilbert JG, Korf I, Lapp H, Lehvaslaiho H, Matsalla C, Mungall CJ, Osborne BI, Pocock MR, Schattner P, Senger M, Stein LD, Stupka E, Wilkinson MD, Birney E.
Genome Res. 12(10):1611-8 (2002). [PubMed]
Freely available [License (Artistic)]
|
NCBI
|
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ.
J. Mol. Biol. 215:403-410 (1990). [PubMed]
|
|
Disprot VL3H
|
Predicting intrinsic disorder from amino acid sequence.
Obradovic Z, Peng K, Vucetic S, Radivojac P, Brown CJ, Dunker AK.
Proteins. 53 Suppl 6:566-72 (2003). [PubMed]
|
 EMBOSS
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EMBOSS: The European Molecular Biology Open Software Suite
Rice P, Longden I, Bleasby A.
Trends in Genetics 16(6): 276-277 (2000).
Freely available [License (GPL and LGPL)]
|
|
GMAP/PMAP
|
GMAP: A Genomic Mapping and Alignment Program for mRNA and EST Sequences
Wu TD, Watanabe CK.
Bioinformatics 31:1869-75 (2005). [Abstract | Manuscript PDF]
Freely available [see file `COPYING' in package]
|
 HMMER
|
Profile Hidden Markov Models.
Eddy SR.
Bioinformatics, 14:755-763 (1998). [PDF]
Freely available [License (GPL)]
|
 JMol
|
http://jmol.sourcefource.net
Freely available [License (GPL)]
|
|
Logical Depth HMMer
|
Accelerated HMMer
Freely distributable derived data is identical to Sean Eddy's
academic HMMer.
|
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Prospect
|
Protein threading using PROSPECT: Design and evaluation.
Xu Y, Xu D.
Proteins: Structure, Function, and Genetics. 40(3):343-54 (2000).
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PSIPred
|
Protein secondary structure prediction based on position-specific scoring matrices.
Jones DT.
J. Mol. Biol. 292:195-202 (1999).
Freely available (Para 8: "...may be made available...if access is granted free of charge...")
|
PyMOL
|
The PyMOL Molecular Graphics System
DeLano WL.
http://www.pymol.org (2002).
Freely available [License]
|
SignalP 3.0
|
Improved prediction of signal peptides: SignalP 3.0.
Bendtsen JD, Nielsen H, von Heijne G, and Brunak S.
J. Mol. Biol., 340:783-795 (2004). [PDF]
|
TMHMM 2.0c
|
Predicting Transmembrane Protein Topology with a Hidden Markov Model: Application to Complete Genomes.
Krogh A, Larsson B, von Heijne G, and Sonnhammer ELL.
J. Mol. Biol. 305:567-580 (2001).
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| Other Software used by Unison |
 Apache web server
|
Freely available [License (Apache)]
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GIMP
|
Freely available [License (GPL)
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GNOME
|
Freely available [License (GPL)
|
 GNU/Free Software Foundation tools
|
Free, of course [License (GPL or LGPL)]
|
 Linux
|
Freely available [License (GPL)]
|
OpenOffice
|
Varies [License]
|
 Perl
|
Freely available [License (Artistic)]
|
 PostgreSQL
|
Freely available [License (BSD)]
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| Support |
 |
Genentech Corporate site
Genentech Bioinformatics public web pages |
|